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Rh-negative Mother & their treatment in Bangladesh.



During pregnancy your Gynecologist will suggest to test your blood is Rh negative or positive. 

If the result outcome is Positive , then its Ok, If not , you have to proper precaution. 


Why ?

The reason is not that complicated, 

If the mother is Rh-negative, her immune system treats Rh-positive fetal cells as if they were a foreign substance. The mother's body makes antibodies against the fetal blood cells. These antibodies may cross back through the placenta into the developing baby. They destroy the baby's circulating red blood cells.

When red blood cells are broken down, they make bilirubin. This causes an infant to become yellow (jaundiced). The level of bilirubin in the infant's blood may range from mild to dangerously high.

Firstborn infants are often not affected unless the mother had past miscarriages or abortions. This would sensitize her immune system. This is because it takes time for the mother to develop antibodies. All children she has later who are also Rh-positive may be affected.

In a study done by TRANSFUSION MEDICINE DEPARTMENT OF DHAKA MEDICAL COLLEGE HOSPITAL, there about 3% Mother who has Rh Negative blood carrier.

For the Rh negative mother, Although it has very less chance to affect in their firstborn baby , but we should not ignore this situation. 

As per USFDA guideline the treatment is giving 1st dosage of Rho(D) Immune Globulin (Human) between 26-28 weeks of pregnancy, and If your baby is found to be Rh-positive at birth, you will receive a second dose within 72 hours after delivery. 

The administration should done by intramuscular (IM) injection. 

As per The Directorate General of Drug Administration (DGDA), Currently in Bangladesh Market, Two product is available of Rho(D) Immune Globulin (Human).

One is Rhophylac 300 by CSL Behring AG (Generic), and another one is RhoGAM by Kedrion Biopharma USA (Originator brand). 


For more information, please contact with any Gynecologist nearby you.
- Kavin The Pharmacist 








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